題目1：Yarrowia lipolytica: A Versatile Microbial Workhorse for Expanding Nature’s Biosynthetic Capacity
報(bào)告人：徐鵬 博士
時(shí) 間：2019-7-9下午4:00-5:00
地 點(diǎn): 化工與能源學(xué)院210會(huì)議室
講座內(nèi)容
Yarrowia lipolytica is an oleaginous yeast that has been substantially engineered for production of oleochemcials and drop-in transportation fuels. It has been considered as a ‘generally recognized as safe’ (GRAS) organism for the production of organic acids in the food and nutraceutical industry. The high precursor acetyl-CoA and malonyl-CoA flux along with the versatile carbon-utilization capability makes this yeast as a superior host to upgrade low-value carbons into high-value pharmaceuticals and plant natural products (PNPs). Bacteria system in general is less efficient to express the complex gene cluster of plant natural product pathway. Unlike bacteria, yeast has developed spatially separated organelles to partition specialized metabolic functions into distinct cellular compartments. In this talk, I will present strategies to build genetic toolkits to streamline the genetic/genome modification for Y. lipolytica. ?I will also present strategies to harness the endogenous acetyl-CoA/malonyl-CoA/HMG-CoA metabolism toward engineering efficient yeast cell factories to produce complex oleochemicals, terpenes, polyketides and aromatic commodity chemicals. We identified pathway limitations and assessed genetic engineering strategies to elevate the level of acetyl-CoA, malonyl-CoA, HMG-CoA and NADPH. This work will provide a testbed for engineering Y. lipolytica and expanding nature’s biosynthetic capacity to produce complex fuels and chemicals from renewable feedstocks.
演講人簡(jiǎn)歷
徐鵬, 博士, 馬里蘭大學(xué)（Baltimore分校區(qū)）化工與生化工程系擔(dān)任助理教授，2013至2016年在麻省理工學(xué)院Greg Stephanopoulos教授課題組完成了博士后，2013年從倫斯勒理工學(xué)院(RPI)化學(xué)與生物工程系獲得博士學(xué)位，導(dǎo)師為Mattheos Koffas。2016年在馬里蘭大學(xué)組建合成生物學(xué)與智能控制實(shí)驗(yàn)室，擔(dān)任實(shí)驗(yàn)室主任。2003年，在江南大學(xué)生物工程學(xué)院獲得生物工程本科學(xué)位，2006年獲得生化工程碩士學(xué)位。目前發(fā)表論文40余篇，被引2154余次，分別發(fā)表在Nature communications、PNAS、Nature Biotechnology和Metabolic Engineering等雜志。目前擔(dān)任Metabolic Engineering 編委，曾獲得2012年“國(guó)家優(yōu)秀自費(fèi)留學(xué)生獎(jiǎng)學(xué)金”。研究領(lǐng)域包括代謝工程、合成生物學(xué)、生物智能控制、遺傳工具開(kāi)發(fā)、數(shù)學(xué)建模等。
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