2013.06.07，我院吳緬/梅一德教授研究組在The EMBO Journal上在線發(fā)表題為“XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling”的文章
時間：2021-04-12 21:23:01學院：生命科學學院學校：中國科學技術大學
作 者：黃 星、吳正升、梅一德、吳 緬
Abstract：
The primary role of autophagy is adaption to starvation. However, increasing evidence suggests that autophagy inhibition also plays an important role in tumorigenesis. Upregulation of X-linked inhibitor of apoptosis (XIAP) has been associated to a variety of human cancers, yet the underlying mechanisms remain obscure. Here, we report that XIAP suppresses autophagy by exerting a previously unidentified ubiquitin E3 ligase activity towards Mdm2, which is a negative regulator of p53. XIAP controls serum starvation-induced autophagy downstream of the PI3K/Akt pathway. In mouse models, inhibition of autophagy by XIAP promotes tumorigenecity of HCT116 cells. XIAP-mediated autophagy inhibition is also largely validated in clinical tumour samples. These findings reveal a novel XIAP-Mdm2-p53 pathway that mediates the inhibition of autophagy, by which XIAP may contribute to tumorigenesis.版權與免責聲明：本網(wǎng)頁的內容由收集互聯(lián)網(wǎng)上公開發(fā)布的信息整理獲得。目的在于傳遞信息及分享，并不意味著贊同其觀點或證實其真實性，也不構成其他建議。僅提供交流平臺，不為其版權負責。如涉及侵權，請聯(lián)系我們及時修改或刪除。郵箱：sales@allpeptide.com